Isoenzymatic characterization of Colombian strains of Trypanosoma cruzi.
نویسندگان
چکیده
Laboratorio de Parasitología Molecular, Departamento de Microbiología, Facultad de Ciencias, Universidad Javeriana, Carrera 7 No. 43-82, Ed. Felix Restrepo, Of.111, Santafé de Bogotá, Colombia *Laboratorio de Parasitología, Instituto Nacional de Salud, Av. El Dorado con Carrera 50, Santafé de Bogotá, Colombia **Instituto de Genética, Facultad de Medicina, Universidad Javeriana, Carrera 7 No. 40-62, Santafé de Bogotá, Colombia
منابع مشابه
Population genetic analysis of Colombian Trypanosoma cruzi isolates revealed by enzyme electrophoretic profiles.
Although Colombia presents an enormous biological diversity, few studies have been conducted on the population genetics of Trypanosoma cruzi. This study was carried out with 23 Colombian stocks of this protozoa analyzed for 13 isoenzymatic loci. The Hardy-Weinberg equilibrium, the genetic diversity and heterogeneity, the genetic relationships and the possible spatial structure of these 23 Colom...
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Twenty-four Trypanosoma cruzi stocks isolated from vectors and from human and Didelphis marsupialis hosts from highly separated sylvatic localities in Colombia were characterized by isoenzyme and schizodeme analyses. The stocks were collected primarily from sylvatic ecotopes representing areas of low, moderate, and high endemicity for Chagas' diseases in Colombia. Parasites were characterized m...
متن کاملIn vitro susceptibility of Trypanosoma cruzi strains from Santander, Colombia, to hexadecylphosphocholine (miltefosine), nifurtimox and benznidazole.
INTRODUCTION The current chemotherapy for Chagas disease is unsatisfactory with only two drugs available for treatment. Research to discover new drugs for Chagas disease is urgent. Hexadecyl-phosphocholine (HPC, miltefosine) has been demonstrated to have in vitro activity against Trypanosoma cruzi parasites, but its activity on different Colombian T. cruzi strains is not known. OBJECTIVE To e...
متن کاملOral transmission of Chagas disease: importance of Trypanosoma cruzi biodeme in the intragastric experimental infection.
Oral transmission of Trypanosoma cruzi has been suspected when epidemic episodes of acute infection were observed in areas devoid of domiciled insect vectors. Considering that the distribution of T. cruzi biodemes differs in sylvatic and domestic cycles, results of studies on biodemes can be of interest regarding oral transmission. The infectivity of T. cruzi strains of different biodemes was t...
متن کاملVariation in susceptibility to benznidazole in isolates derived from Trypanosoma cruzi parental strains.
In this work, the susceptibility to benznidazole of two parental Trypanosoma cruzi strains, Colombian and Berenice-78, was compared to isolates obtained from dogs infected with these strains for several years. In order to evaluate the susceptibility to benznidazole two groups of mice were infected with one of five distinct populations isolated from dogs as well as the two parental strains of T....
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عنوان ژورنال:
- Memorias do Instituto Oswaldo Cruz
دوره 93 6 شماره
صفحات -
تاریخ انتشار 1998